Way out of my league but fascinating. Didn't see m
Post# of 154376
(Total Views: 621)
Posted On: 02/19/2025 5:15:27 AM
Way out of my league but fascinating. Didn't see mention of CCR5...(and could be way off base) but seems like these findings might compliment leronlimab's MOA: stopping metastasis. ???
Medical Press
'Scientists discover the 'roadmap' that aggressive cancer uses to spread'
'New research published in Nature Communications reveals how cancer cells are altered by their surroundings, enabling them to change their shape and break out of a tumor. The discovery, which is the culmination of almost a decade of research that began at King's, paves the way for treatments that will tackle cancer before it can spread.'
Nature Communications
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis
--In agreement with previous work, we show that vinculin dynamics and protein levels can change when cells are under confinement, leading to the loss of strong cell-ECM adhesions.
--Our observations suggest that matrix organization, cytoskeletal features and transcriptional activation are strong predictors of aggressive behavior of cancer cells. Patients with these tumour architectures could benefit from therapies targeting these pro-invasive and pro-survival programs linked to collagen dynamics. For example, pan-LOX inhibitors are under active preclinical investigation for highly desmoplastic tumour types, thus PXS-5505 is a strong candidate in future clinical trials62,63,64. Furthermore, YAP1 (NCT04590664) or JAK165 inhibitors are currently being tested in preclinical and clinical studies to treat cancer. We have used cancer as a model, but our work will shed light on other physiological conditions in which matrix organisation could influence cell migration and cell survival, such as during development, fibrosis, aging, wound healing, and immune responses.
Best--CGC
Medical Press
'Scientists discover the 'roadmap' that aggressive cancer uses to spread'
'New research published in Nature Communications reveals how cancer cells are altered by their surroundings, enabling them to change their shape and break out of a tumor. The discovery, which is the culmination of almost a decade of research that began at King's, paves the way for treatments that will tackle cancer before it can spread.'
Nature Communications
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis
--In agreement with previous work, we show that vinculin dynamics and protein levels can change when cells are under confinement, leading to the loss of strong cell-ECM adhesions.
--Our observations suggest that matrix organization, cytoskeletal features and transcriptional activation are strong predictors of aggressive behavior of cancer cells. Patients with these tumour architectures could benefit from therapies targeting these pro-invasive and pro-survival programs linked to collagen dynamics. For example, pan-LOX inhibitors are under active preclinical investigation for highly desmoplastic tumour types, thus PXS-5505 is a strong candidate in future clinical trials62,63,64. Furthermore, YAP1 (NCT04590664) or JAK165 inhibitors are currently being tested in preclinical and clinical studies to treat cancer. We have used cancer as a model, but our work will shed light on other physiological conditions in which matrix organisation could influence cell migration and cell survival, such as during development, fibrosis, aging, wound healing, and immune responses.
Best--CGC
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