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There is a mouse study investigating combination t

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Post# of 154595
(Total Views: 585)
Posted On: 01/28/2025 12:14:13 AM
Posted By: ohm20
Re: mfglola #149574
Quote:
There is a mouse study investigating combination therapy of CCR2/CCR5 antagonist and FGF21 analogue which suggested an additive effect.



I've read those results using cencriviroc. I should have expounded and said I was looking for any direct effects of CCR5 on FGF21. Cencriviroc being a CCR2/CCR5 blockade drug is not a direct comparison to leronlimab. Cencriviroc has low occupancy for CCR5 and does little for CCL5 (RANTES) or CCR5 specific ligand downregulation. In the past I've read posts about a possible combo with leronlimab but as I've stated it would not be good to completely shut down the actions of other receptors or proteins.


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