Interesting read on newly discovered cause of one
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Posted On: 01/05/2025 9:39:11 PM
Interesting read on newly discovered cause of one type of Alzheimer's Disease. I'm not sure if Leronlimab would be a treatment for this type. Ohm20 might have more insight on this?
Most people encounter cytomegalovirus (CMV) during childhood, and after the initial infection the virus remains in the body for life, usually dormant.
By the age of 80, 9 out of 10 people will have CMV's telltale antibodies in their blood. A type of herpesvirus, the pathogen spreads via body fluids (such as breast milk, saliva, blood, and semen) but only when the virus is active.
In one unlucky group, the study showed, the virus may have found a biological loophole where it can remain active long enough to hitch a ride up the gut-brain axis 'superhighway', known more officially as the vagus nerve.
On arriving at the brain, the active virus has the potential to aggravate the immune system and contribute to the development of Alzheimer's disease.
It's a concerning possibility, but it also means antiviral drugs might be able to prevent some people from developing Alzheimer's, especially if researchers can develop blood tests to quickly detect active CMV infection in the gut.
Earlier this year, some members of the team from Arizona State University announced a link between a subtype of microglia associated with Alzheimer's disease, named CD83(+) because of the cell's genetic quirks, and raised levels of immunoglobulin G4 in the transverse colon, which hinted at some kind of infection.
https://www.sciencealert.com/scientists-disco...alzheimers
Most people encounter cytomegalovirus (CMV) during childhood, and after the initial infection the virus remains in the body for life, usually dormant.
By the age of 80, 9 out of 10 people will have CMV's telltale antibodies in their blood. A type of herpesvirus, the pathogen spreads via body fluids (such as breast milk, saliva, blood, and semen) but only when the virus is active.
In one unlucky group, the study showed, the virus may have found a biological loophole where it can remain active long enough to hitch a ride up the gut-brain axis 'superhighway', known more officially as the vagus nerve.
On arriving at the brain, the active virus has the potential to aggravate the immune system and contribute to the development of Alzheimer's disease.
It's a concerning possibility, but it also means antiviral drugs might be able to prevent some people from developing Alzheimer's, especially if researchers can develop blood tests to quickly detect active CMV infection in the gut.
Earlier this year, some members of the team from Arizona State University announced a link between a subtype of microglia associated with Alzheimer's disease, named CD83(+) because of the cell's genetic quirks, and raised levels of immunoglobulin G4 in the transverse colon, which hinted at some kind of infection.
https://www.sciencealert.com/scientists-disco...alzheimers
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