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So my daughter is in Bali with Dengue Fever. T

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Post# of 155036
(Total Views: 615)
Posted On: 01/03/2025 5:00:15 AM
Posted By: ohm20
Re: KenChowder #148962
Quote:
So my daughter is in Bali with Dengue Fever.



The best to your daughter.

Quote:
I think it's a longshot, because the following are not on Ohm's list:



Dengue fever was on my list of diseases to look at.

It's not a longshot.

Quote:
Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development
https://pmc.ncbi.nlm.nih.gov/articles/PMC4515137/



Quote:
Some potential targets are Fc receptors, as well as some proinflammatory cytokine and chemokines, including CCR2 and CCR4 receptors. Moreover, PAFR blockade represents another novel target to modulate the inflammatory response



I decided to look at PAFR (platelet-activating factor receptor) which I've ran into here and there. There are quite a few similarities between the cytokines that PAFR is said to activate and those of CCR5. I wondered whether PAFR was involved with inducing CCR5 expression or whether CCR5 activated PAFR. Activation of PAFR by it's ligand PAF will increase CCR5 expression. But PLA2 (phospholipase A2) is what creates PAF from Lyso-PAF and PLA2 is increased by CCR5. So CCR5 expression in response to bodily insult increases, which increases PLA2, which activates PAF which binds to PAFR which further increases CCR5 resulting in even further increases in inflammatory cytokines. I have not seen that pathway shown anywhere else before but I believe that may be what is happening.



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