It looks like the ISR pathway would either be inte
Post# of 155038
(Total Views: 515)
Posted On: 01/02/2025 11:44:33 PM
Re: Buddyboy20 #148866
Quote:
It looks like the ISR pathway would either be interrupted or regulated by Leronlimab's down regulation of elF2a, and PKR.
Maybe Ohm20 could look this over and verify this statement.
elF2a and PKR would be more inline for viral challenges.
Unfortunately sci-hub does not have that full science paper yet. From the synopsis (https://www.cell.com/neuron/abstract/S0896-6273(24)00875-4 ) the cellular stress is most likely driven by inflammatory assaults accompanied by mitochondrial dysfunction. Leronlimab can help in both cases. In the case of lipids leronlimab would reduce both triglycerides and LDL cholesterol. Lipids go toxic when there is an overabundance of them. APOE4 which is implicated in Alzheimer's is integral in lipid movement and activity. CCR5 blockade has been shown to restrain APOE4s effects.
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