Maybe OHM can offer assistance on this So I ask

Maybe OHM can offer assistance on this

So I asked ChatGPT "AI" what is the difference between Leronlimab and Merck's two failed drugs.



Leronlimab, Vibostolimab, and Favezelimab are all monoclonal antibodies that have different targets, mechanisms of action, and therapeutic indications. Here's a breakdown of each:

1. Leronlimab
Target: CCR5 (C-C chemokine receptor type 5)
Mechanism of Action:
Leronlimab is a CCR5 antagonist. It binds to the CCR5 receptor, which is expressed on the surface of certain immune cells, such as T-cells and macrophages. By blocking this receptor, Leronlimab inhibits the entry of certain viruses (notably HIV) into these cells. CCR5 is also involved in immune cell trafficking and inflammation.
Therapeutic Uses:
HIV: Leronlimab is being investigated as a treatment for HIV, as blocking CCR5 can prevent HIV from entering immune cells.
Cancer: There is ongoing research into using Leronlimab as an immunotherapy for cancers, including metastatic breast cancer, due to its potential to modulate the immune system.
Autoimmune and Inflammatory Conditions: Leronlimab is also being studied for conditions like Crohn's disease and multiple sclerosis.


2. Vibostolimab
Target: PD-1 (Programmed cell death protein 1)
Mechanism of Action:
Vibostolimab is a PD-1 inhibitor. PD-1 is an immune checkpoint receptor expressed on T-cells. Normally, when PD-1 binds to its ligands (PD-L1 or PD-L2), it dampens T-cell activity, preventing the immune system from attacking normal cells but also limiting its ability to attack cancer cells.
By inhibiting PD-1, Vibostolimab releases the "brakes" on the immune system, allowing T-cells to more effectively recognize and destroy cancer cells.
Therapeutic Uses:
Cancer Immunotherapy: Vibostolimab is being investigated primarily for the treatment of various cancers, including non-small cell lung cancer (NSCLC) and melanoma, among others. It works as part of the broader class of immune checkpoint inhibitors, similar to drugs like pembrolizumab (Keytruda) and nivolumab (Opdivo).



3. Favezelimab
Target: PD-1 (Programmed cell death protein 1)
Mechanism of Action:
Favezelimab is also a PD-1 inhibitor, similar to Vibostolimab. It works by blocking the PD-1 receptor on T-cells, preventing the binding of PD-L1 and PD-L2, and thereby activating T-cells to attack tumors.
Therapeutic Uses:
Like Vibostolimab, Favezelimab is being studied for cancer treatment, specifically for use in solid tumors such as melanoma, non-small cell lung cancer (NSCLC), and head and neck squamous cell carcinoma (HNSCC).
Favezelimab has shown promise in clinical trials as a monotherapy and in combination with other therapies to enhance immune responses against cancer.
Key Differences:
Target:

Leronlimab targets CCR5, a receptor involved in immune cell migration and viral entry.
Vibostolimab and Favezelimab both target PD-1, a checkpoint receptor on T-cells involved in immune regulation.
Mechanism of Action:

Leronlimab inhibits immune cell trafficking and viral entry, potentially helping with HIV, cancer, and autoimmune conditions.
Vibostolimab and Favezelimab enhance immune responses by blocking PD-1, allowing T-cells to attack cancer cells more effectively.
Therapeutic Indications:

Leronlimab is being studied primarily for HIV, autoimmune diseases, and certain cancers.
Vibostolimab and Favezelimab are being developed as cancer immunotherapies for various solid tumors, particularly in combination with other therapies.
Development Status:

Leronlimab is in clinical trials, mainly focusing on HIV and cancers.
Vibostolimab and Favezelimab are also in clinical trials for cancer immunotherapy, specifically PD-1-related indications.



Summary:
Leronlimab: Targets CCR5 to block viral entry and modulate immune responses, with research into HIV, cancer, and autoimmune diseases.
Vibostolimab and Favezelimab: Both are PD-1 inhibitors designed to enhance the immune system's ability to fight cancer, with trials in a variety of cancers.