Interesting article. They determined that collagen

Interesting article. They determined that collagen mutation and degradation could be the cause of Interocular Glaucoma. But, they didn't spend much time on what causes the degradation and/or mutation of the collagen and pathway. I asked if inflammation could be responsible for the degradation and mutation of ocular collagen. This was the reply:

Yes, inflammation can cause collagen degradation in the eye, which can contribute to further inflammation:
Inflammation and matrix metalloproteinases (MMPs)
When inflammation is chronic, it activates MMPs, which are enzymes that break down collagen and elastin. This can impede healing and contribute to more inflammation.
Collagen and immune regulators
Collagen contains binding sites for inflammatory and immune regulators. When collagen is fragmented, it can promote the recruitment of pro-inflammatory immune cells.
Oxidative stress
Inflammatory cells can secrete free radicals, which can lead to oxidative stress and tissue damage. Oxidative stress can also contribute to inflammation.
Inflammation can be caused by many factors, including pathogens, allergic reactions, and dry eye disease.

Therefore, maybe inflammatory markers might be detected before the collagen degradation and mutation takes place. If so, perhaps the inflammation could be treated with a CCR5 antagonist to prevent physical damage to the collagen. I wonder if indications of early chronic inflammation could be detected in routine eye exams? Maybe time should be spent on designing tests to rapidly detect inflammatory markers. Just freethinking it.