“… to prevent further seeding of the reservoir

“… to prevent further seeding of the reservoir…”

Here’s your answer. Mechanism perhaps unknown but could be quite simple. The reservoirs need to be re-seeded bc Virus dies off eventually within viral reservoirs.

If virus dies off in reservoirs, And is normally re-seeded by normal blood supply, And AAV LL achieves 100% Receptor Occupancy on CCR5, Then as virus dies off floating around in bloodstream looking for a vacant receptor, and Then no living virus eventually remains in the bloodstream to “further seed…” the reservoir. Therefore, the Reservoir eventually becomes vacant of living virus. Seems to be complete by 12 months or so.

It’s a bit of a mechanical explanation, but with 100% RO, it might not be necessary to flush reservoirs of virus. Just starve em out, Seige style.

"Conclusions: Finding a treatment that can prevent reservoir establishment and spread after the first 48 hours has been elusive. The results of this study suggest that the combination of A RT, bNAbs, and CCR5 blockade via Leronlimab synergize in an undefined mechanism to prevent further seeding of the reservoir early after infection, and may even permanently reduce it. Further studies are warranted to study this combinatorial effect in more detail. "