Jay's choice "Trifluridine/tipiracil (TAS-102
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"Trifluridine/tipiracil (TAS-102) plus bevacizumab is a third-line treatment for metastatic colorectal cancer (mCRC)".
The first and second lines are described as follows:
"Chemotherapy: The cornerstone of mCRC treatment, chemotherapy is used in combination with other agents. Some examples of chemotherapy drugs include fluorouracil (FU), oxaliplatin, and irinotecan.
Antiangiogenic agents: These agents are used in combination with chemotherapy.
Molecularly targeted agents: These agents are used in combination with chemotherapy.
Immune checkpoint inhibitors: These agents are used in the treatment of mCRC.
Anti-EGFR agents: These agents, such as cetuximab or panitumumab, are used in combination with chemotherapy for patients with wild-type RAS and BRAF."
As minimum, LL actions include inhibition of antiangiogenesis and immune checkpoints. Do we know why Dr. Lalezari has chosen to do the third line?
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Le-Ron-Li-Mab, and they have not.