Zika virus mAb's: Blocking the neonatal Fc rece
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Posted On: 10/02/2024 9:36:20 PM
Zika virus mAb's:
Blocking the neonatal Fc receptor (FcRn) is a potential strategy to reduce the risk of Zika virus (ZIKV) infection in a fetus:
FcRn and ZIKV:
FcRn is a receptor found in placental cells that helps mediate viral infections. ZIKV and its envelope immunogen can enter and be transferred across placental cells that express FcRn.
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Other strategies to neutralize the Zika virus include:
Using monoclonal antibodies such as EDE1-C10, EDE1-C8, or SlgN-3C
Using the pseudo-broad antibody MZ4
____
Haven't looked @ these Mab's yet & forget which one our LL-PLS said was very toxic & still failed to block Zika
Blocking the neonatal Fc receptor (FcRn) is a potential strategy to reduce the risk of Zika virus (ZIKV) infection in a fetus:
FcRn and ZIKV:
FcRn is a receptor found in placental cells that helps mediate viral infections. ZIKV and its envelope immunogen can enter and be transferred across placental cells that express FcRn.
____
Other strategies to neutralize the Zika virus include:
Using monoclonal antibodies such as EDE1-C10, EDE1-C8, or SlgN-3C
Using the pseudo-broad antibody MZ4
____
Haven't looked @ these Mab's yet & forget which one our LL-PLS said was very toxic & still failed to block Zika
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