Most of the examples you give of most drug companies fail but its also almost all of them companies only had 1 egg in their basket that had a chance to do only one thing and failed and after that they didn't have a leg to stand on. Good thing cydy has a future blockbuster drug and about 20 legs to stand on. Your only right until your wrong you could short 10 companies big time until they are 5 feet under and it only takes one to come out ontop for the shorts to be completely buried. They could lose big profits they made from shorting 30 companies all of one potentially future giant.