Hematopoietic Growth Factors Regulate the Entry of

Hematopoietic Growth Factors Regulate the Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

https://pubmed.ncbi.nlm.nih.gov/39201584/

Cysteine-cysteine chemokine receptor 5 (CCR5) in brain endothelial cells , but not the cell adhesion molecules mediating neuroinflammation-related infiltration of monocyte-derived macrophages, modulates SCF+G-CSF-enhanced monocyte-endothelial cell adhesion. Blocking CCR5 or genetically deleting CCR5 reduces monocyte-endothelial cell adhesion induced by SCF+G-CSF. The SCF+G-CSF-enhanced recruitment of bone marrow-derived monocytes/macrophages into the cerebral perivascular space is also reduced in adult CCR5 knockout mice. This study demonstrates the role of SCF and G-CSF in regulating the entry of monocytes into the adult brain to replenish perivascular macrophages.

Credit Bluemoon on I Village.

Keywords: adhesion; chemokine receptor 5; endothelial cells; granulocyte colony-stimulating factor; hematopoietic growth factors; macrophages; monocytes; stem cell factor.