“autoimmune transcriptional circuit drives FOXP3
Post# of 146073
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“…may be key drivers of dysfunctional Tregs in autoimmune diseases…”
“…Here, Sumida et al. found that Tregs isolated from individuals with multiple sclerosis, an autoimmune disease of the central nervous system, had increased expression of the short isoform of PR domain zinc finger protein 1 (PRDM1-S), which destabilized expression of the essential Treg transcription factor FOXP3 and induced Treg dysfunction mediated through SGK1, a salt-sensing kinase.”
https://www.science.org/doi/10.1126/scitranslmed.adp1720
FOXP3 is on OHM’s regulation list for Leronlimab
https://investorshangout.com/post/view?id=6701453
At some point, perhaps triggered by the Cytodyn inflammation study results, the world will wake up and realize targeting the CCR5 receptor is central to immune modulation and the many disease states related to it. The aforementioned study hints at trotting off to a new target for drug intervention but needs to stand back and appreciate molecular orchestration and tuning is a different but related target. We need some cash or BP interest in dusting off the next Collosus machine to illuminate the landscape here, which is BEGGING for pursuit. Ask anyone struggling (including physicians) with some of the neurodegenerative diseases like MS that are part of immune dysfunction.
For the curious: most are aware of the Enigma machine and the decryption efforts at Bletchley park, I think fewer are aware Collosus was envisioned with solving infinitely more difficult ciphers but it is also a great story and one with direct implications for the D-Day landings at Normandy. David Price’ book Geniuses at War on this subject is a great read.
https://cs.stanford.edu/people/eroberts/cours...Cold%20War.
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