Alzheimer's again: Restoring Cognitive Function
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Posted On: 08/22/2024 9:23:49 PM
Alzheimer's again:
Restoring Cognitive Function in Lab Mice
Now, with support from research and training grants from the Knight Initiative, they have shown that by blocking the kynurenine pathway in lab mice with Alzheimer’s Disease, they can improve, or even restore, cognitive function by reinstating healthy brain metabolism.
https://scitechdaily.com/stanford-reverses-co...lism-drug/
Hungry Neurons
In the brain, kynurenine regulates production of the energy molecule lactate, which nourishes the brain ’s neurons and helps maintain healthy synapses. Andreasson and her fellow researchers specifically looked at the enzyme indoleamine-2,3-dioxygenase 1 — or IDO1, for short — which generates kynurenine. Their hypothesis was that increases in IDO1 and kynurenine triggered by accumulation of amyloid and tau proteins would disrupt healthy brain metabolism and lead to cognitive decline .
Restoring Cognitive Function in Lab Mice
Now, with support from research and training grants from the Knight Initiative, they have shown that by blocking the kynurenine pathway in lab mice with Alzheimer’s Disease, they can improve, or even restore, cognitive function by reinstating healthy brain metabolism.
https://scitechdaily.com/stanford-reverses-co...lism-drug/
Hungry Neurons
In the brain, kynurenine regulates production of the energy molecule lactate, which nourishes the brain ’s neurons and helps maintain healthy synapses. Andreasson and her fellow researchers specifically looked at the enzyme indoleamine-2,3-dioxygenase 1 — or IDO1, for short — which generates kynurenine. Their hypothesis was that increases in IDO1 and kynurenine triggered by accumulation of amyloid and tau proteins would disrupt healthy brain metabolism and lead to cognitive decline .
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