So, are we dosing for 4 weeks and then just waitin

So, are we dosing for 4 weeks and then just waiting to see if the mOS is longer than 10.8 months or is the ORR an endpoint that we'll be able to see sooner? If we're just dosing for 4 weeks and then waiting that seems like a Covid situation where after 4 weeks the drug is no longer in the system and progress due to LL will decline. Thanks for the responses.