Anti-drug antibodies were also made against long acting leronlimab.
What is really interesting to me is the situation where the macaque developed the anti-drug antibodies, then completely stopped making leronlimab. Then, after a year of making zero leronlimab, spontaneously started making leronlimab all over again, by itself. There was no re-injection of AAV to initiate that spontaneous resurgence of the auto-manufacture of leronlimab.
First off, in order to develop anti-drug antibodies, something had to tell the immune system that the self-produced leronlimab were foreign. Then the immune system went through the process of developing its immune response against it and ended up with anti-drug antibodies against that leronlimab.
The immune system ramped up its production of the anti-drug antibodies to render the auto-produced leronlimab useless and maintained an undetectable level of that leronlimab in the blood serum for a year.
Then, all of a sudden, leronlimab was measured again in the blood serum spontaneously, without re-injection of the AAV delivery system.
Let's take the perspective that the leronlimab which was being made in the body was considered an antigen. However, not a very robust antigen. Let's consider that the body perceived it to be something like a "dead" virus. Therefore, we can consider that the self-produced leronlimab was perceived by the body to even be a "vaccine" against what would be the live virus, ie, the live leronlimab which really does not exist, but the body does not know that..
So, initially, the body develops its initial response to the dead virus and develops sufficient response as antibodies which drop leronlimab down to zero detectable in the serum.
But, with repeated doses of the "dead" virus, as the body continues to manufacture the self producing leronlimab, which is "the vaccine", the auto-produced leronlimab, the body became increasingly fatigued of producing any further antibody against it, In essence, after repeated bombardment of vaccination after vaccination after vaccination, it no longer considered the dead virus to be foreign. Rather, it began to consider it as self.
The T-Regs / Suppressor cells became increasingly convinced that this auto produced leronlimab was self. and suppressed the B-Cells from making any more antibodies.
Consider this video from 6 minute time to the 14 minute
Germinal Centers/url]
What is really interesting to me is the situation where the macaque developed the anti-drug antibodies, then completely stopped making leronlimab. Then, after a year of making zero leronlimab, spontaneously started making leronlimab all over again, by itself. There was no re-injection of AAV to initiate that spontaneous resurgence of the auto-manufacture of leronlimab.
First off, in order to develop anti-drug antibodies, something had to tell the immune system that the self-produced leronlimab were foreign. Then the immune system went through the process of developing its immune response against it and ended up with anti-drug antibodies against that leronlimab.
The immune system ramped up its production of the anti-drug antibodies to render the auto-produced leronlimab useless and maintained an undetectable level of that leronlimab in the blood serum for a year.
Then, all of a sudden, leronlimab was measured again in the blood serum spontaneously, without re-injection of the AAV delivery system.
Let's take the perspective that the leronlimab which was being made in the body was considered an antigen. However, not a very robust antigen. Let's consider that the body perceived it to be something like a "dead" virus. Therefore, we can consider that the self-produced leronlimab was perceived by the body to even be a "vaccine" against what would be the live virus, ie, the live leronlimab which really does not exist, but the body does not know that..
So, initially, the body develops its initial response to the dead virus and develops sufficient response as antibodies which drop leronlimab down to zero detectable in the serum.
But, with repeated doses of the "dead" virus, as the body continues to manufacture the self producing leronlimab, which is "the vaccine", the auto-produced leronlimab, the body became increasingly fatigued of producing any further antibody against it, In essence, after repeated bombardment of vaccination after vaccination after vaccination, it no longer considered the dead virus to be foreign. Rather, it began to consider it as self.
The T-Regs / Suppressor cells became increasingly convinced that this auto produced leronlimab was self. and suppressed the B-Cells from making any more antibodies.
Consider this video from 6 minute time to the 14 minute
Germinal Centers/url]
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