Investors Hangout Stock Message Boards Logo
  • Mailbox
  • Favorites
  • Boards
    • The Hangout
    • NASDAQ
    • NYSE
    • OTC Markets
    • All Boards
  • Whats Hot!
    • Recent Activity
    • Most Viewed Boards
    • Most Viewed Posts
    • Most Posted
    • Most Followed
    • Top Boards
    • Newest Boards
    • Newest Members
  • Blog
    • Recent Blog Posts
    • Recently Updated
    • News
    • Stocks
    • Crypto
    • Investing
    • Business
    • Markets
    • Economy
    • Real Estate
    • Personal Finance
  • Market Movers
  • Interactive Charts
  • Login - Join Now FREE!
  1. Home ›
  2. Stock Message Boards ›
  3. Stock Boards ›
  4. Clene Inc. (CLNN) Message Board

Researchers Identify New Gene Behind ALS Onset

Message Board Public Reply | Private Reply | Keep | Replies (0)                   Post New Msg
Edit Msg () | Previous | Next


Post# of 154
(Total Views: 109)
Posted On: 07/29/2024 4:57:54 PM
Avatar
Posted By: NetworkNewsWire
Researchers Identify New Gene Behind ALS Onset

Scientists have discovered a new mutation that may cause amyotrophic lateral sclerosis to develop. Amyotrophic lateral sclerosis, or ALS in short, is a neurodegenerative illness that weakens an individual’s muscles and affects their physical function.

It starts by degenerating nerve cells in the brain and spinal cord, affecting an individual’s voluntary control of legs and arms. The illness leads to trouble breathing, swallowing and may cause slurred speech.

The illness is rare, with an average incidence of 1.4 to 2.4 cases in every 100,000 individuals annually. Additionally, the illness, which is sometimes referred to as motor neuron disease, has no known cause and no known cure. However, scientists have determined that at least 5% to 10% of ALS cases are inherited. This comes after clinicians observed that between 2009–2022, the illness’ incidence was higher in Spain’s La Rioja region.

This allowed scientists from Sant Pau Hospital and Sant Pau Research Institute to discover that the ARPP21 gene may cause ALS. Sant Pau Hospital is a national referral center for neuromuscular illnesses in Spain.

The objective of the study, led by Ricard Rojas-García, was to find a common gene associated with motor neuron disease in people who hadn’t tested positive for known ALS genes. For their study, the scientists carried out whole-genome sequencing of twelve individuals with motor neuron disease from the La Rioja region. Of this number, five had a family history of the illness.

The scientists also included additional cases from nearby areas and members of affected families in their study.

They discovered a shared missense mutation in the ARPP21 gene in 10 individuals with ALS from seven unrelated families. These individuals possessed no mutations in other genes known to cause the illness.

The cyclic AMP-regulated phosphoprotein 21 gene (ARPP21) is widely expressed in the brain. This gene plays a role in RNA metabolism, which is central to motor-neuron disease pathophysiology. Most of the genes involved in ALS development encode RNA-binding proteins.

Oriol Dols-Icardo, the first author of the study, stated that the ARPP21 gene would help clinicians to diagnose motor-neuron disease more precisely while also opening the door to studies on new personalized treatments.

Dols-Icardo added that this discovery would also allow researchers to study the function of this RNA-binding protein in ALS. The scientists hope that clinicians and researchers globally will examine their patients and databases to see if this mutation is present in other areas. Such information could be pivotal in the efforts of companies such as Clene Inc. (NASDAQ: CLNN) that are engaged in developing next-gen treatments for this condition.

NOTE TO INVESTORS: The latest news and updates relating to Clene Inc. (NASDAQ: CLNN) are available in the company’s newsroom at https://ibn.fm/CLNN

Please see full terms of use and disclaimers on the BioMedWire website applicable to all content provided by BMW, wherever published or re-published: http://BMW.fm/Disclaimer




(0)
(0)




Clene Inc. (CLNN) Stock Research Links


  1.  
  2.  


  3.  
  4.  
  5.  






Investors Hangout

Home

Mailbox

Message Boards

Favorites

Whats Hot

Blog

Settings

Privacy Policy

Terms and Conditions

Disclaimer

Contact Us

Whats Hot

Recent Activity

Most Viewed Boards

Most Viewed Posts

Most Posted Boards

Most Followed

Top Boards

Newest Boards

Newest Members

Investors Hangout Message Boards

Welcome To Investors Hangout

Stock Message Boards

American Stock Exchange (AMEX)

NASDAQ Stock Exchange (NASDAQ)

New York Stock Exchange (NYSE)

Penny Stocks - (OTC)

User Boards

The Hangout

Private

Global Markets

Australian Securities Exchange (ASX)

Euronext Amsterdam (AMS)

Euronext Brussels (BRU)

Euronext Lisbon (LIS)

Euronext Paris (PAR)

Foreign Exchange (FOREX)

Hong Kong Stock Exchange (HKEX)

London Stock Exchange (LSE)

Milan Stock Exchange (MLSE)

New Zealand Exchange (NZX)

Singapore Stock Exchange (SGX)

Toronto Stock Exchange (TSX)

Contact Investors Hangout

Email Us

Follow Investors Hangout

Twitter

YouTube

Facebook

Market Data powered by QuoteMedia. Copyright © 2025. Data delayed 15 minutes unless otherwise indicated (view delay times for all exchanges).
Analyst Ratings & Earnings by Zacks. RT=Real-Time, EOD=End of Day, PD=Previous Day. Terms of Use.

© 2025 Copyright Investors Hangout, LLC All Rights Reserved.

Privacy Policy |Do Not Sell My Information | Terms & Conditions | Disclaimer | Help | Contact Us