How do you know that higher levels of inflammation

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How do you know that higher levels of inflammation lead to lower levels of T3 and T4?

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It's been reported in medical papers but the exact mechanism hasn't been elucidated as far as I've seen. It could be as simple as inflammation mediated mitochondrial dysfunction which leronlimab fixes. I would have to track the entire T3/T4 pathway to get a better handle on it. But I've learned to conserve my time for the more important aspects otherwise this becomes a more than full time job.