Deeper Dive into DUR-928 Hypothetical Scenario and
Post# of 70
(Total Views: 236)
Posted On: 05/03/2024 12:26:17 PM
Deeper Dive into DUR-928 Hypothetical Scenario and Implications:
Transplant Counts: Let's assume that approximately half the transplants in the study were in patients who would have died without one. Recategorizing these patients as alive would change the results significantly.
Revised Mortality: Factoring those transplants into the 'alive' category would likely lower the observed mortality rates in both the larsucosterol groups and the SOC group, likely resulting in a statistically significant difference between them.
Stronger Endpoint: By recognizing the lifesaving power of transplants, the analysis becomes a better reflection of the overall effectiveness of larsucosterol in improving patient outcomes beyond simply postponing death.
Conclusion: In my opinion even though the results for 90-day mortality didn't quite reach statistical significance, they strongly suggest that larsucosterol has the potential to be a transformative therapy for alcohol-associated hepatitis. Recategorizing transplant patients as alive would likely solidify the statistical significance of the findings. This, coupled with the strong trends observed across other outcomes and the drug's favorable safety profile, presents a compelling case for further investigation and potential approval.
Transplant Counts: Let's assume that approximately half the transplants in the study were in patients who would have died without one. Recategorizing these patients as alive would change the results significantly.
Revised Mortality: Factoring those transplants into the 'alive' category would likely lower the observed mortality rates in both the larsucosterol groups and the SOC group, likely resulting in a statistically significant difference between them.
Stronger Endpoint: By recognizing the lifesaving power of transplants, the analysis becomes a better reflection of the overall effectiveness of larsucosterol in improving patient outcomes beyond simply postponing death.
Conclusion: In my opinion even though the results for 90-day mortality didn't quite reach statistical significance, they strongly suggest that larsucosterol has the potential to be a transformative therapy for alcohol-associated hepatitis. Recategorizing transplant patients as alive would likely solidify the statistical significance of the findings. This, coupled with the strong trends observed across other outcomes and the drug's favorable safety profile, presents a compelling case for further investigation and potential approval.
(1)
(0)