Thanks Z, that’s quite interesting. I wonder
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Posted On: 04/13/2024 1:46:48 PM
Thanks Z, that’s quite interesting.
I wonder if insulin resistance may explain Covid triggering diabetes 2 in some patients.
HDL is the good cholesterol. I think Ohm showed a link between CcR5 blockade and lowering bad cholesterol. LDL. I wonder if we could impact this reduction in HDL also.
And then ferroptosis. Some in my family have high iron in blood (hemochromatosis). I do not. But my brother just had his second hip replaced at 60 possibly attributable to high iron. It also leads to organ, tissue, bone issues later in life.
Ferritin is a universal intracellular protein that stores iron and releases over time.
This paper describes the many effects on cell death, tissue and organ damage due to ferroptosis. It includes fibrosis in all major organs. Both connected to elevated inflammation. That I’m sure we can help with.
https://www.hindawi.com/journals/omcl/2022/5295434/
Abstract
Ferroptosis is a new type of programmed cell death with unique morphological, biochemical, and genetic features. From the initial study of histomorphology to the exploration of subcellular organelles and even molecular mechanisms, a net connecting ferroptosis and fibrosis is being woven and formed. Inflammation may be the bridge between both processes. In this review, we will discuss the ferroptosis theory and process and the physiological functions of ferroptosis, followed by a description of the pathological effects and the underlying mechanisms of ferroptosis in the pathogenesis of tumorigenesis, ischemic damage, degenerative lesions, autoimmune diseases, and necroinflammation. We then focus on the role of ferroptosis in the fibrosis process in the liver, lung, kidney, heart, and other organs. Although the molecular mechanism of ferroptosis has been explored extensively in the past few years, many challenges remain to be resolved to translate this information into antifibrotic practice, which is becoming a promising new direction in the field of fibrotic disease prevention and treatment.
I wonder if insulin resistance may explain Covid triggering diabetes 2 in some patients.
HDL is the good cholesterol. I think Ohm showed a link between CcR5 blockade and lowering bad cholesterol. LDL. I wonder if we could impact this reduction in HDL also.
And then ferroptosis. Some in my family have high iron in blood (hemochromatosis). I do not. But my brother just had his second hip replaced at 60 possibly attributable to high iron. It also leads to organ, tissue, bone issues later in life.
Ferritin is a universal intracellular protein that stores iron and releases over time.
This paper describes the many effects on cell death, tissue and organ damage due to ferroptosis. It includes fibrosis in all major organs. Both connected to elevated inflammation. That I’m sure we can help with.
https://www.hindawi.com/journals/omcl/2022/5295434/
Abstract
Ferroptosis is a new type of programmed cell death with unique morphological, biochemical, and genetic features. From the initial study of histomorphology to the exploration of subcellular organelles and even molecular mechanisms, a net connecting ferroptosis and fibrosis is being woven and formed. Inflammation may be the bridge between both processes. In this review, we will discuss the ferroptosis theory and process and the physiological functions of ferroptosis, followed by a description of the pathological effects and the underlying mechanisms of ferroptosis in the pathogenesis of tumorigenesis, ischemic damage, degenerative lesions, autoimmune diseases, and necroinflammation. We then focus on the role of ferroptosis in the fibrosis process in the liver, lung, kidney, heart, and other organs. Although the molecular mechanism of ferroptosis has been explored extensively in the past few years, many challenges remain to be resolved to translate this information into antifibrotic practice, which is becoming a promising new direction in the field of fibrotic disease prevention and treatment.
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