Good stuff Katangolo and Bio4. The nittygrit

Good stuff Katangolo and Bio4.

The nittygritty in this good discussion of Long Covid is below. It describes in Ohmlike fashion the way Leronlimab acutes as an immune system modulator, which of course is of intense interest for Long Covid and other autoimmune disorders.

Quote:

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Of importance a greater numerical decrease in symptom severity score was seen for 19 of the 24 symptoms for leronlimab treated individuals compared to placebo treated individuals (Fig. 1).... The trial also observed significantly increased blood cell surface CCR5 from baseline to day 56 in leronlimab treated symptomatic responders but not in leronlimab treated non-responders or those participants who received placebo. To our surprise, rather that showing that PASC is mediated by persisting inflammation after acute COVID-19 we had to conclude that at least in some individuals with PASC there is an unexpected immune downmodulation prior to leronlimab treatment which was normalized after leronlimab treatment.

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