ALP reduction in the liver (alkaline phosphatase level)
ALP reduction in the liver (alkaline phosphatase level) and Pruritis (chronic itchy skin) seem to be the big results.
So how does Gilead get to $4B?
AbstractBackground & Aims: Primary biliary cholangitis (PBC) can result in life-altering chole-static pruritus and fatigue, but treatment options are limited. Seladelpar, a peroxi-some proliferator-activated receptor-delta (PPARδ) agonist, has demonstrated potent anti- cholestatic effects in clinical studies. This open- label, uncontrolled phase 2 study in PBC patients evaluated the effects of 1-year of seladelpar treatment on measures of pruritus and quality of life.Methods: Self- reported experiences of 101 PBC patients were collected at baseline and after 1 year of seladelpar treatment using the pruritus visual analog scale (VAS), 5D- itch scale, and PBC-40 questionnaires along with bile acid profiles.Results: In patients with moderate–to- severe pruritus, substantial improvement in pruritus was seen in 58% and 93% of patients in 5/10 mg and 10 mg treatment groups, respectively. After 1 year, patients reporting improvement substantially out-numbered those who worsened in the total 5-D itch (including individual domains) and PBC-40 (itch and fatigue domains) questionnaires. Improvement in sleep distur-bance at 1-year was reported in 81% (5/10 mg) and 78% (10 mg) of the patients with baseline itch- related sleep disturbance by 5-D itch score with similar results using the PBC- 40 sleep questionnaire. Seladelpar-treated patients had significant reductions of 46% (5/10 mg) and 31% (10 mg) in the serum bile acid precursor C4 and reductions of up to 38% in serum bile acids
I guess. If it makes your dick hard, help you lose weight, or helps you drink more alcohol with your bros then there’s a huge market for that shit, yo!
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