ALP reduction in the liver (alkaline phosphatase level)

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chazzledazzle chazzledazzle #141007
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ALP reduction in the liver (alkaline phosphatase level) and Pruritis (chronic itchy skin) seem to be the big results.

So how does Gilead get to $4B?

AbstractBackground & Aims: Primary biliary cholangitis (PBC) can result in life-altering chole-static pruritus and fatigue, but treatment options are limited. Seladelpar, a peroxi-some proliferator-activated receptor-delta (PPARδ) agonist, has demonstrated potent anti- cholestatic effects in clinical studies. This open- label, uncontrolled phase 2 study in PBC patients evaluated the effects of 1-year of seladelpar treatment on measures of pruritus and quality of life.Methods: Self- reported experiences of 101 PBC patients were collected at baseline and after 1 year of seladelpar treatment using the pruritus visual analog scale (VAS), 5D- itch scale, and PBC-40 questionnaires along with bile acid profiles.Results: In patients with moderate–to- severe pruritus, substantial improvement in pruritus was seen in 58% and 93% of patients in 5/10 mg and 10 mg treatment groups, respectively. After 1 year, patients reporting improvement substantially out-numbered those who worsened in the total 5-D itch (including individual domains) and PBC-40 (itch and fatigue domains) questionnaires. Improvement in sleep distur-bance at 1-year was reported in 81% (5/10 mg) and 78% (10 mg) of the patients with baseline itch- related sleep disturbance by 5-D itch score with similar results using the PBC- 40 sleep questionnaire. Seladelpar-treated patients had significant reductions of 46% (5/10 mg) and 31% (10 mg) in the serum bile acid precursor C4 and reductions of up to 38% in serum bile acids

I guess. If it makes your dick hard, help you lose weight, or helps you drink more alcohol with your bros then there’s a huge market for that shit, yo!

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