CCR5 and brain metastases in breast cancer http

CCR5 and brain metastases in breast cancer

https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.15243

CCR5 is everywhere

Excerpt: "...Compared with the G1 group, the total number of T cells in the G2 group increased significantly (Figures 1d and 2e), and the proportion of C3_CCR5 clusters increased nearly two-fold (Figure 2f). A lot of evidence has shown that CCR5 plays an important role in memory T cells, such as promoting memory response and antigen sensitivity of CD4+ memory T cells17 and mediating the migration of bystander-activated CD8+ T cells.18 It can be speculated that in the G2 group, C3_CCR5 increased significantly and suppressed the tumor by indirectly promoting other immune effector cells, which leads to a better prognosis. Meanwhile, compared with the G1 group, DEGs of C3_CCR5 in the G2 group showed enrichment in immune cell regulation and cell
adhesion functions, such as positive regulation of cell–cell adhesion and positive regulation of leukocyte activation (Figure 2g). It is worth noting that the C4_SCGB2A2, which accounts for about 10% of the G1 group, almost disappeared in the G2 group.

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