Thank you ohm.
I appreciate your perspective.
So in patient's with HIV on ART, where do you suppose they are laying down their fibrotic tissue? Wouldn't it be within their arteries leading to atherosclerosis? Which leads to blood clots, DVTs, Pulmonary Embolism PE and Myocardial Infarction MI?
In the heart leading to reduced contractile capacity?
In the brain leading to reduced brain function, alzheimers, etc...
In the kidney leading to CKD?
In the pancreas leading to reduced capacity for digest and onset of diabetes II?
In the GI tract leading to reduced gastric motility?
In the spleen leading to impaired RBC maintenance?
In the lungs leading to reduced pulmonary function?
Yes, in all these organs and systems, scarring would reduce their capacity to perform their work. The organ would scar and as a result, its output would be reduced, whereas in the liver, it regenerates and scars and its output remains relatively the same, but with MASH, liver enzymes climb pointing to how sick it is.
Following an MI, the heart tissue that died ends up scarring. That injured heart puts out cardiac enzymes pointing to its own sickness.
I appreciate your opinion here and I'm thankful you agree with me. But what do you think of this:
equation idea is probably the worst idea you could come up with
Do you think it is a good idea to span the output of the equation to go from say (-25 -10 0 10 25) where values from -10 to +10 would be considered "normal healthy patients". Values from + 10 to +25 would be considered "Pre-Inflammatory". Values from -10 to -25 would be considered "Pre-Proliferative". Values in excess of +25 would be considered Inflammatory and values less than -25 would be considered Proliferative.
Pre-Inflammatory, patients who have only been on ART therapy for say less than 5 years who are beginning to develop the signs and symptoms of chronic inflammation
Inflammatory, patients on ART for longer than 5 years who have already developed the signs and symptoms of chronic ART illness
Pre-Proliferative patients that are younger, who despite being on ART therapy, who are exceptionally healthy, who eat right, who exercise daily, and actively have decided not to participate in any activity which could negatively affect their capacity to heal
Proliferative patients would also be younger individuals who are exceptionally active, who lift weights, who develop strong muscle mass, strong tendons and ligament reflecting active muscle and fibrosis without any inflammatory process.
I appreciate your perspective.
So in patient's with HIV on ART, where do you suppose they are laying down their fibrotic tissue? Wouldn't it be within their arteries leading to atherosclerosis? Which leads to blood clots, DVTs, Pulmonary Embolism PE and Myocardial Infarction MI?
In the heart leading to reduced contractile capacity?
In the brain leading to reduced brain function, alzheimers, etc...
In the kidney leading to CKD?
In the pancreas leading to reduced capacity for digest and onset of diabetes II?
In the GI tract leading to reduced gastric motility?
In the spleen leading to impaired RBC maintenance?
In the lungs leading to reduced pulmonary function?
Yes, in all these organs and systems, scarring would reduce their capacity to perform their work. The organ would scar and as a result, its output would be reduced, whereas in the liver, it regenerates and scars and its output remains relatively the same, but with MASH, liver enzymes climb pointing to how sick it is.
Following an MI, the heart tissue that died ends up scarring. That injured heart puts out cardiac enzymes pointing to its own sickness.
Quote:I think you've done a very good job of outlining exactly how they're going to do it. Capturing the thousand alterations made by leronlimab would be cost prohibitive but the broader that panel the better.
I appreciate your opinion here and I'm thankful you agree with me. But what do you think of this:
equation idea is probably the worst idea you could come up with
Do you think it is a good idea to span the output of the equation to go from say (-25 -10 0 10 25) where values from -10 to +10 would be considered "normal healthy patients". Values from + 10 to +25 would be considered "Pre-Inflammatory". Values from -10 to -25 would be considered "Pre-Proliferative". Values in excess of +25 would be considered Inflammatory and values less than -25 would be considered Proliferative.
Pre-Inflammatory, patients who have only been on ART therapy for say less than 5 years who are beginning to develop the signs and symptoms of chronic inflammation
Inflammatory, patients on ART for longer than 5 years who have already developed the signs and symptoms of chronic ART illness
Pre-Proliferative patients that are younger, who despite being on ART therapy, who are exceptionally healthy, who eat right, who exercise daily, and actively have decided not to participate in any activity which could negatively affect their capacity to heal
Proliferative patients would also be younger individuals who are exceptionally active, who lift weights, who develop strong muscle mass, strong tendons and ligament reflecting active muscle and fibrosis without any inflammatory process.
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