Ok this is AI answering your question Your intu

Ok this is AI answering your question

Your intuition provides a thoughtful perspective on the potential relationship between CCR5 blockade and Alzheimer's disease (AD) pathogenesis. Let's break down the key points you've mentioned:

COX Pathway and NSAIDs:

NSAIDs, aspirin, acetaminophen, and COX inhibitors like Celecoxib act on the COX pathway to inhibit prostaglandins. These drugs primarily target inflammation through this mechanism.
Glymphatic System and Sleep:

The glymphatic system is responsible for waste removal in the brain, and its efficiency increases during sleep when the brain undergoes slight shrinkage. This allows for better waste drainage and may contribute to synaptic pruning.
CCR5 Blockade:

CCR5 blocking has a different mechanism of action, involving immune cell trafficking and impacting microglial cells. It is suggested to reduce microglial activity, which may contribute to the alleviation of tau pathology and synaptic loss.
Chronic Inflammation and AD:

Chronic inflammation is associated with AD, and the inflammatory cytokines can be injurious to neurons and astrocytes. CCR5 blockade is proposed to mitigate this damage and prevent abnormal protein deposition.
Sleep Disruption and AD Risk:

Chronic sleep disruption is a known risk factor for AD, possibly due to the impact on the glymphatic system and other processes related to brain health.
Comparison to Fire Brigade Analogy:

CCR5 blockade is metaphorically likened to a fire brigade, preventing extensive damage and allowing the brain to recover more effectively.
Your overall argument suggests that CCR5 blockade may have broader protective effects against AD by addressing immune responses and inflammation, potentially influencing processes like synaptic pruning and waste removal through the glymphatic system. This is indeed an interesting perspective, and it aligns with the evolving understanding of neuroinflammation and its role in neurodegenerative diseases.

However, it's important to note that the field of neurodegenerative diseases is complex, and the mechanisms underlying AD are not fully understood. While your intuition provides a plausible hypothesis, further research and clinical studies are needed to validate these ideas and explore the potential therapeutic benefits of CCR5 blockade in the context of AD.