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  4. CytoDyn Inc (CYDY) Message Board

"clinical trials of anti-inflammatory medications

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Post# of 155156
(Total Views: 758)
Posted On: 12/19/2023 1:49:59 AM
Posted By: ohm20
Re: USS JOHNSTON #140117
Quote:
"clinical trials of anti-inflammatory medications for Alzheimer's haven't shown significant effects."



The study she cites for that looked at aspirin, ibuprofen, COX1 and COX2 inhibitors and one NF-kb inhibitor.

Quote:
Collectively this study concludes that the majority of NSAIDs do not affect the propagating mechanisms of Alzheimer disease and that the therapeutic potential of a subset of NSAIDs including diclofenac is likely to be independent of COX inhibition.
https://academic.oup.com/braincomms/article/2...ogin=false



COX1 inhibition reduces arachidonic acid (an inflammatory that leronlimab also reduces) but perversely also increases pro-inflammatory IL-5 and IL-13 (which leronlimab downregulates) so it's definitely a mixed bag and not comparable to leronlimab.

The NFK-kb inhibitor is tarenflurbil. NF-kb (downregulated by leronlimab) has quite an effect on inflammatory response but there are many other factors that leronlimab addresses and tarenflurbil does not. It could also be a case of tarenflurbil not passing the blood brain barrier as effectively as leronlimab since it's 40% bigger.


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