Thank you ohm, your reply is much appreciated.
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Posted On: 12/13/2023 4:50:05 AM
Thank you ohm, your reply is much appreciated.
I was very much intrigued by your statement here:
I thought that was fascinating and I understand what you stated completely. Just, when you say, "it causes HIV viral reservoirs", what is "it"? The rapid rise in CCR5 due to the second infection? or is it the second infection itself, or is it the reduced number of CD4 and CD8 cells available, (which were utilized to fight off the "other" infection), which would have otherwise prevented the release of HIV viral reservoirs?
Ohm, please, I'm not imposing and if you are too busy or strapped, I completely understand, and time is of no concern to me, but if you are nudged, then, I was hoping you wouldn't mind describing in general terms how the normal, CD4 count, CD8 count & the CD4/CD8 ratio are generally affected by the development of HIV infection and then even worse, as it progresses into full blown AIDS.
Also, how does the addition of ART affect those same cell counts and ratio in both the progression of HIV and then into full blown AIDS, so as to observe varying counts among the cell types within these stages.
At your convenience, all of us are so used to waiting. Thank you so much for everything.
I was very much intrigued by your statement here:
Quote:
Those blips while using leronlimab may have two causes. The other infection may cause a rapid rise in CCR5 that leronlimab does not cover in time and/or it causes HIV viral reservoirs to release their stores of HIV virus. If it's the first, leronlimab will eventually occupy all CCR5 again and stop further reproduction. If it's the second, then that released virus will have no CCR5 open with which to reproduce. Either way it would explain why the virus goes back down with continued use of leronlimab.
I thought that was fascinating and I understand what you stated completely. Just, when you say, "it causes HIV viral reservoirs", what is "it"? The rapid rise in CCR5 due to the second infection? or is it the second infection itself, or is it the reduced number of CD4 and CD8 cells available, (which were utilized to fight off the "other" infection), which would have otherwise prevented the release of HIV viral reservoirs?
Quote:
This references an active HIV infection. Under ART treatment you can see a low CD4 count along with a high CD8 count. Some will have a very good CD4 count along with a high CD8 count which will show more of a balance but it's still in an overreactive immune state. You want to see a normal state for both in relation to any current infections.
Ohm, please, I'm not imposing and if you are too busy or strapped, I completely understand, and time is of no concern to me, but if you are nudged, then, I was hoping you wouldn't mind describing in general terms how the normal, CD4 count, CD8 count & the CD4/CD8 ratio are generally affected by the development of HIV infection and then even worse, as it progresses into full blown AIDS.
Also, how does the addition of ART affect those same cell counts and ratio in both the progression of HIV and then into full blown AIDS, so as to observe varying counts among the cell types within these stages.
At your convenience, all of us are so used to waiting. Thank you so much for everything.
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