Good morning you all longs... A little visit do

Good morning you all longs...

A little visit down memory street.

A recent publication "Long COVID-19 Symptoms Remedied by Anti-Viral Treatment in Neurosurgical Patients" presents a limited study in which Acyclovir (ACV) resolves different long-covid related injuries.

https://thescipub.com/abstract/ajidsp.2023.39.44

Quote:

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This study presents case studies of long COVID-19 patients whose symptoms resolved with the chronic use of acyclovir. A novel explanation of the mechanism of symptom resolution is presented. It is the hope other researchers will contribute to this observation.

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In studying the mechanism of action of ACV in "Exploiting the Anti-HIV-1 Activity of Acyclovir: Suppression of Primary and Drug-Resistant HIV Isolates and Potentiation of the Activity by Ribavirin"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346610/

I found ... guess what ???

Quote:

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RESULTS
ACV suppresses replication of primary HIV-1 isolates. Previously, we reported that ACV suppresses replication of four laboratory HIV-1 strains, CXCR4-tropic LAI.04 (HIV-1LAI.04), CCR5-tropic BaL, SF162, and AD8, in ex vivo infected human lymphoid tissues (21). Here, we evaluated the susceptibility of four primary isolates to ACV: HIV-196USNG31 and HIV-197USNG30 of clade C, HIV-196USNN20 of clade A, and HIV-1ME1 of clade B. Isolate HIV-196USNG31 uses CCR3, CCR5 , and CXCR4; HIV-196USNN20 has a broad coreceptor utilization, including CCR2B, CCR3, CCR4, CCR5 , CXCR4, Bob, and Bonzo; HIV-197USNG30 and HIV-1ME1 are exclusively CCR5 tropic.

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So, once again, there is a link between a feasible treatment to Long-Covid and CCR-5 related suppression. If we could only get our act together and do a clinical trial, we would find out what others are finding out, luckily just now in exploratory stage.

We have a drug, it works, we just need to demonstrate it.

Good rest of weekend to you all.