Quote from ohm20: Trodelvy is a topoisomerase
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Posted On: 08/25/2023 12:43:57 PM
Quote from ohm20:
I read this morning that Merck has discontinued a late-stage study for a combo cancer therapy. Note the mention of PD-L1. Here is the article.
Aug 25 (Reuters) - Merck & Co (MRK.N) and partner Eisai (4523.T) said on Friday they will shut down a late-stage study testing an experimental combination therapy for a type of head and neck cancer after an interim analysis showed it failed to prolong lives of patients.
The therapy, Merck's blockbuster drug Keytruda in combination with Eisai's Lenvima, failed to show statistical significance in extending overall survival, one of the three main goals of the study, the companies said.
The companies were testing the combination for head and neck squamous cell carcinoma — a cancer that develops in the mucous membranes of the mouth, nose and throat — in patients with recurrent or metastatic form of the disease and whose tumors contain a protein called PD-L1.
This type of cancer is especially common in parts of Southeast Asia, and the companies estimate it to lead to more than 66,000 new diagnoses in the United States this year.
"Our clinical program is designed to help accelerate our efforts to tackle difficult-to-treat, advanced cancers, and while the outcome may not always be what we anticipate, we know that this is part of clinical development," said Eisai executive Corina Dutcus.
The therapy met other main goals of reducing tumor size and improving the time to death or disease worsening after treatment compared to placebo.
The companies are testing the combination to treat a range of cancers, including those affecting the lungs and stomach.
The Keytruda-Lenvima combination therapy is approved in the United States for the treatment of a type of kidney cancer and certain types of cancers in the lining of the uterus.
https://www.reuters.com/business/healthcare-p...023-08-25/
Quote:
Trodelvy is a topoisomerase inhibitor that stops DNA repair in tumor cells. Leronlimab stops DNA repair by downregulating GRP78. Also an abundance of GRP78 can inhibit the effect of topoisomerase inhibitors so leronlimab should be more effective than Trodelvy in that regard.
Leronlimab downregulates the receptor for PD - L1 (Keytruda's target) called PD -1. So leronlimab does what both Trodelvy and Keytruda do and even more.
I read this morning that Merck has discontinued a late-stage study for a combo cancer therapy. Note the mention of PD-L1. Here is the article.
Aug 25 (Reuters) - Merck & Co (MRK.N) and partner Eisai (4523.T) said on Friday they will shut down a late-stage study testing an experimental combination therapy for a type of head and neck cancer after an interim analysis showed it failed to prolong lives of patients.
The therapy, Merck's blockbuster drug Keytruda in combination with Eisai's Lenvima, failed to show statistical significance in extending overall survival, one of the three main goals of the study, the companies said.
The companies were testing the combination for head and neck squamous cell carcinoma — a cancer that develops in the mucous membranes of the mouth, nose and throat — in patients with recurrent or metastatic form of the disease and whose tumors contain a protein called PD-L1.
This type of cancer is especially common in parts of Southeast Asia, and the companies estimate it to lead to more than 66,000 new diagnoses in the United States this year.
"Our clinical program is designed to help accelerate our efforts to tackle difficult-to-treat, advanced cancers, and while the outcome may not always be what we anticipate, we know that this is part of clinical development," said Eisai executive Corina Dutcus.
The therapy met other main goals of reducing tumor size and improving the time to death or disease worsening after treatment compared to placebo.
The companies are testing the combination to treat a range of cancers, including those affecting the lungs and stomach.
The Keytruda-Lenvima combination therapy is approved in the United States for the treatment of a type of kidney cancer and certain types of cancers in the lining of the uterus.
https://www.reuters.com/business/healthcare-p...023-08-25/
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