NetworkNewsBreaks – Genprex Inc. (NASDAQ: GNPX)
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Genprex (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, has signed an exclusive license agreement with the University of Pittsburgh. The agreement grants Genprex worldwide, exclusive rights to a patent application and related technology for a gene therapy targeting both type 1 and type 2 diabetes. The therapy utilizes Pdx1 (“Pdx1”) and MafA (“MafA”) genes controlled by an MafB (“MafB”) promoter and administered through an adeno-associated virus (“AAV”) vector directly into the pancreatic duct. Preclinical data from nonhuman primate models of type 1 diabetes show promising results, with significant decreases in insulin requirements, increased c-peptide levels and improved glucose tolerance. The addition of this technology strengthens Genprex’s diabetes gene therapy program, and the company aims to optimize the product candidates through further preclinical studies. “We are continuing to build a fortress of protection and a powerful intellectual property portfolio for our diabetes gene therapy program,” said Genprex president and CEO Rodney Varner in the press release. “The addition of this license to MafB promoter technology expands and strengthens the potential for this novel, gene therapy to treat type 1 and type 2 diabetes. In licensing this latest exclusive technology, which joins several others that provide us with multiple diabetes gene therapy combinations, we have valuable rights over what we believe are the most innovative, emerging diabetes gene therapies.”
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