Excerpt: The levels of CCR5 and its chemokine liga
Post# of 154013
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Posted On: 06/27/2023 10:25:36 AM
Excerpt: The levels of CCR5 and its chemokine ligands are increased in the brains of pre-manifesting Huntington disease (HD) and tauopathy mouse models. CCR5 accumulation might be due to a self-amplifying mechanism, since CCR5 is a substrate of autophagy and CCL5-CCR5-mediated autophagy inhibition impairs CCR5 degradation. Furthermore, pharmacological, or genetic inhibition of CCR5 rescues mTORC1-autophagy dysfunction and improves neurodegeneration in HD and tauopathy mouse models, suggesting that CCR5 hyperactivation is a pathogenic signal driving the progression of these diseases.
https://www.tandfonline.com/doi/full/10.1080/...23.2221921
https://www.tandfonline.com/doi/full/10.1080/...23.2221921
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