APOE (the ALZ gene) and a protein called reelin
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Posted On: 05/16/2023 6:11:24 PM
APOE (the ALZ gene) and a protein called reelin and the receptor route.
https://www.cnn.com/2023/05/15/health/alzheim...index.html
She carried two copies of a change in her APOE3 gene that was nicknamed the Christchurch mutation. It seems to have decreased the activity of the APOE3 protein. Like reelin, APOE is a signaling molecule that is known to play a role in shaping a person’s risk for Alzheimer’s.
And it turns out that there is a link between these two cases: The receptors on cells for reelin are the same receptors for APOE.
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