“Seems like CCR5 deletion doesn’t have an impa
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Posted On: 01/25/2023 10:19:08 PM
“Seems like CCR5 deletion doesn’t have an impact on MS. So we can’t treat MS?”
“The expression of CCL5 may be disrupted by gene mutations and
downregulation of its receptor CCR5. For example, a genetic poly- morphism, ie, a single nucleotide substitution (A to G) at 403 position of the CCL5 gene promoter results in lower expression of CCL5, or in the 303 position of its receptor CCR5 promoter sequence, X32 (32 base pair deletion) of CCR5 gene coding region is associated with a lower MS severity index [79]. Although a significant increase in CCR5 expression has been found in MS patients, it appears that besides the CCR5Δ32 mutation, other haplotypes or polymorphisms, as well as other possible epigenetic and genetic factors, are vital for CCR5 expression in multiple sclerosis patients [37]. In addition, based on a summary of one review, there appears to be no consensus on the association of CCR5Δ32 mu- tations with MS, and the differences in the reports may reflect the ge- netic background of the study population and their exposure to en- vironmental factors [37].”
“The expression of CCL5 may be disrupted by gene mutations and
downregulation of its receptor CCR5. For example, a genetic poly- morphism, ie, a single nucleotide substitution (A to G) at 403 position of the CCL5 gene promoter results in lower expression of CCL5, or in the 303 position of its receptor CCR5 promoter sequence, X32 (32 base pair deletion) of CCR5 gene coding region is associated with a lower MS severity index [79]. Although a significant increase in CCR5 expression has been found in MS patients, it appears that besides the CCR5Δ32 mutation, other haplotypes or polymorphisms, as well as other possible epigenetic and genetic factors, are vital for CCR5 expression in multiple sclerosis patients [37]. In addition, based on a summary of one review, there appears to be no consensus on the association of CCR5Δ32 mu- tations with MS, and the differences in the reports may reflect the ge- netic background of the study population and their exposure to en- vironmental factors [37].”
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