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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156228/
“Although most research on the pathogenesis of MS has focused on the role of CD4 T cells, in fact, compared to most animal models, the main T cells found in the central nervous system of MS patients are CD8 T cells, suggesting that CD8 T Cells may play an important role in human disease [52]. There is growing evidence indicates that successful treatments are often related to changes in many other lymphocyte subpopulations, including B cells, NK cells, Lti cells, other ILC cells, γδT cells, NKT cells, MAIT cells and innate B cells. These findings not only indicate that multiple lymphocyte subpopulations are involved in the pathogenesis of the disease, but also identify the cells as potential targets for immunotherapy [117].”