Here’s a bit more from the study about which you
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Posted On: 12/27/2022 8:20:23 PM
Here’s a bit more from the study about which you’ve posted an article. The CD4/CD8 balance is something we know LL modulates from CD10/12. Covid trials. And take it with a grain of salt, but Scott Kelly reported that we cross the brain barrier.
“CSF Aging in Health and Cognitive Impairment
Single cell transcriptomics reveals cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment
Cerebrospinal fluid (CSF) contains a tightly regulated immune system. Yet, little is known about how CSF immunity is altered with aging or neurodegenerative disease. Here, we performed single cell RNA sequencing on CSF from 45 cognitively normal subjects ranging from 54-82 years old. We reveal upregulation of lipid transport genes in monocytes with age. We then compared this cohort to 14 cognitively impaired subjects. In cognitively impaired subjects, downregulation of lipid transport genes in monocytes occurred concomitantly with altered cytokine signaling to CD8 T cells. Clonal CD8 T effector memory cells upregulated C-X-C Motif Chemokine Receptor 6 (CXCR6) in cognitively impaired subjects. The CXCR6 ligand, C-X-C Motif Chemokine Ligand 16 (CXCL16) , was elevated in CSF of cognitively impaired subjects, suggesting CXCL16-CXCR6 signaling as a mechanism for antigen-specific T cell entry into the brain. Cumulatively, these results reveal cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.”
“CSF Aging in Health and Cognitive Impairment
Single cell transcriptomics reveals cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment
Cerebrospinal fluid (CSF) contains a tightly regulated immune system. Yet, little is known about how CSF immunity is altered with aging or neurodegenerative disease. Here, we performed single cell RNA sequencing on CSF from 45 cognitively normal subjects ranging from 54-82 years old. We reveal upregulation of lipid transport genes in monocytes with age. We then compared this cohort to 14 cognitively impaired subjects. In cognitively impaired subjects, downregulation of lipid transport genes in monocytes occurred concomitantly with altered cytokine signaling to CD8 T cells. Clonal CD8 T effector memory cells upregulated C-X-C Motif Chemokine Receptor 6 (CXCR6) in cognitively impaired subjects. The CXCR6 ligand, C-X-C Motif Chemokine Ligand 16 (CXCL16) , was elevated in CSF of cognitively impaired subjects, suggesting CXCL16-CXCR6 signaling as a mechanism for antigen-specific T cell entry into the brain. Cumulatively, these results reveal cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.”
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