I hope it works out so that all that is needed is
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I hope it works out so that all that is needed is leronlimab to turn off CCR5 for a while. It looks like it will be a functional cure (drops HIV below detectable levels), but unclear if it will be a sterilizing cure (removes all HIV from the body so don't need any therapy again)
The problem is HIV viral reservoirs. Years ago I calculated that it would take 15 (?) years to naturally clear existing reservoirs. Maraviroc and most certainly leronlimab will elevate the clearing of reservoirs somewhat. But there are other drugs that elevate the clearing of reservoirs. So it's possible that AAV combined with reservoir clearing drugs could effectuate a complete cure.