Kabonk, What is LNP? sorry if its a dumb quest
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Posted On: 12/14/2022 10:52:38 PM
Kabonk,
What is LNP? sorry if its a dumb question.
"Only problem with AAV transgene product (leronlimab) production waning is that you can't re-dose with AAV, as the body builds up immunity to it after the first dose
Now if one could encapsulate leronlimab mRNA in LNP, that could be redosed."
Leronlimab wouldn't be sterilizing/neutralizing It would simply occupy the receptor, so I'm wondering what's on your mind.
" It looks like it will be a functional cure (drops HIV below detectable levels), but unclear if it will be a sterilizing cure (removes all HIV from the body so don't need any therapy again)."
Did you have something in mind concerning the following?
" If it is to be used against HIV, why not just make HIV broadly neutralizing antibodies too, to go with leronlimab?"
Do you know of an HIV broadly neutralizing antibody, or the development efforts of one?
Thanks,
chazzle
What is LNP? sorry if its a dumb question.
"Only problem with AAV transgene product (leronlimab) production waning is that you can't re-dose with AAV, as the body builds up immunity to it after the first dose
Now if one could encapsulate leronlimab mRNA in LNP, that could be redosed."
Leronlimab wouldn't be sterilizing/neutralizing It would simply occupy the receptor, so I'm wondering what's on your mind.
" It looks like it will be a functional cure (drops HIV below detectable levels), but unclear if it will be a sterilizing cure (removes all HIV from the body so don't need any therapy again)."
Did you have something in mind concerning the following?
" If it is to be used against HIV, why not just make HIV broadly neutralizing antibodies too, to go with leronlimab?"
Do you know of an HIV broadly neutralizing antibody, or the development efforts of one?
Thanks,
chazzle
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