Generator asked, "Are there any CXCR6 inhibitors?
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Posted On: 12/14/2022 3:33:05 PM
Re: generactor #131331
Generator asked, "Are there any CXCR6 inhibitors? I googled but didn't see anything on any drugs currently out there."
Read More: https://investorshangout.com/post/view?id=6511006#ixzz7nTjFFiPI
It looks like Leronlimab would take care of CXCR6 over-expression. Additionally, I think it down regulates some of the items that cause CXCR6 to up regulate. According to this research paper CXCR6 binds to the CCL5 ligand. But, really, this is Ohm20's area of expertise.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854301/
"Based on the expression data from degenerating retinae, we identified various CC and CXC ligand-receptor axes that could potentially be involved in the recruitment of migratory cells. These included Ccl5/6/12-Ccr1/Ccr3/Ccr5, Cxcl9/10-Cxcr3, and Cxcl16-Cxcr6 (Figure 1H). We also further investigated the Cxcl1/2/5-Cxcr2 axis, as it was known to recruit MSCs in other degenerative contexts.47,48 Therefore, we performed transwell assays in the presence of small-molecule antagonists of chemokine receptors (Figures 1I and 1J; Figure S2I). In particular, we used inhibitors of the Ccr1, Ccr3, and Ccr5 receptors, a Cxcr2 inhibitor, and a Cxcr6 inhibitor. Of note, we opted for combined inhibition of the three Ccr receptors, as they can all be bound by Ccl5."
Read More: https://investorshangout.com/post/view?id=6511006#ixzz7nTjFFiPI
It looks like Leronlimab would take care of CXCR6 over-expression. Additionally, I think it down regulates some of the items that cause CXCR6 to up regulate. According to this research paper CXCR6 binds to the CCL5 ligand. But, really, this is Ohm20's area of expertise.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854301/
"Based on the expression data from degenerating retinae, we identified various CC and CXC ligand-receptor axes that could potentially be involved in the recruitment of migratory cells. These included Ccl5/6/12-Ccr1/Ccr3/Ccr5, Cxcl9/10-Cxcr3, and Cxcl16-Cxcr6 (Figure 1H). We also further investigated the Cxcl1/2/5-Cxcr2 axis, as it was known to recruit MSCs in other degenerative contexts.47,48 Therefore, we performed transwell assays in the presence of small-molecule antagonists of chemokine receptors (Figures 1I and 1J; Figure S2I). In particular, we used inhibitors of the Ccr1, Ccr3, and Ccr5 receptors, a Cxcr2 inhibitor, and a Cxcr6 inhibitor. Of note, we opted for combined inhibition of the three Ccr receptors, as they can all be bound by Ccl5."
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