Enjay, Nice find. I’ve often wondered about o
Post# of 148281
Nice find. I’ve often wondered about our GVHD efforts. Basically this…
If we can halt GVHD, then bone marrow transplants would be categorically more successful, and the type of HIV cure that the first 3 bone marrow transplant patient have experienced as a cure would also categorically be more possible. Those 3 Patients have replicated the delta32 allele mutation and no longer express CCR5 on their cells. That’s the key of course. Replicate the conditions to have no CCR5 which multiple viruses use to enter T-Cells.
But of course, we walked away from GVHD.
We’ve said that bone marrow transplants aren’t scalable. Of course that’s true. But this guy clearly sees the benefit of Leronlimab in his work.
Luckily for us in the realm of HIV cure, we may prove to be able to produce Leronlimab en vitro utilizing AAV therapy. Reference both Jonah Sachs’s work and his obvious enthusiasm. We may have still an easier and scalable way to replicate the Delta 32 allele mutation in anybody with a SubQ injection, rather than a bone marrow transplant.
We may be able to replicate that by occupying all the CCR5 from within the body. In other words, your familial line will not need to survive the plague, or be a sex worker, to get delta 32 mutation and no CCR5. You and yours maybe can go the pharmacy together before your holiday dinner.
Happy Holidays everyone. And most importantly, Happy New Year! It has to better than last year. Sheez..,