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Motherload - A very large amount of something valuable

ActiPatch has the Motherload of FDA Clearances, Musculoskeletal Pain.

Musculoskeletal Health
World Health Organization
14 July 2022

Key facts
Approximately 1.71 billion people have musculoskeletal conditions worldwide.
Musculoskeletal conditions are the leading contributor to disability worldwide, with low back pain being the single leading cause of disability in 160 countries.
Musculoskeletal conditions significantly limit mobility and dexterity, leading to early retirement from work, lower levels of well-being and reduced ability to participate in society.

Because of population growth and ageing, the number of people living with musculoskeletal conditions and associated functional limitations, is rapidly increasing. WHO is responding to the burden attributed to musculoskeletal conditions across a number of programmatic areas.

Scope
Musculoskeletal health refers to the performance of the locomotor system, comprising intact muscles, bones, joints and adjacent connective tissues. Musculoskeletal impairments comprise more than 150 different diseases/conditions that affect the system and are characterized by impairments in the muscles, bones, joints and adjacent connective tissues leading to temporary or lifelong limitations in functioning and participation. Musculoskeletal conditions are typically characterized by pain (often persistent) and limitations in mobility and dexterity, reducing people’s ability to work and participate in society. Pain experienced in musculoskeletal structures is the most common form of non-cancer pain.

Musculoskeletal conditions are relevant across the life-course – from childhood to older age. They range from those conditions that arise suddenly and are short-lived (such as fractures, sprains and strains, associated with pain and limitations in functioning) though to long-term conditions such as chronic primary low back pain and osteoarthritis.

* Musculoskeletal conditions include conditions that affect:

* Joints, such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, spondyloarthritis;

* Bones, such as osteoporosis, osteopenia and associated fragility fractures, traumatic fractures;

* Muscles, such as sarcopenia;

* Multiple body areas or systems, such as regional (e.g. back and neck pain) and widespread (e.g. fibromyalgia) pain conditions, inflammatory diseases such as connective tissue diseases and vasculitis that have musculoskeletal manifestations, for example systemic lupus erythematosus, or amputation as a result of disease or trauma.

Musculoskeletal conditions are also the highest contributor to the global need for rehabilitation. They are among the largest contributors to the need for rehabilitation services among children and account for approximately two-thirds of all adults in need of rehabilitation (1). Musculoskeletal conditions often co-exist with other noncommunicable diseases and increase the risk of developing other noncommunicable diseases, such as cardiovascular disease (2). People with musculoskeletal conditions are also at higher risk to develop mental health issues.

Magnitude
A recent analysis of Global Burden of Disease (GBD) 2019 data showed that approximately 1.71 billion people globally live with musculoskeletal conditions, including low back pain, neck pain, fractures, other injuries, osteoarthritis, amputation and rheumatoid arthritis (1). While the prevalence of musculoskeletal conditions varies by age and diagnosis, people of all ages everywhere around the world are affected. High-income countries are the most affected in terms of number of people – 441 million – followed by countries in the WHO Western Pacific Region with 427 million and South-East Asia Region with 369 million. Musculoskeletal conditions are also the biggest contributor to years lived with disability (YLDs) worldwide with approximately 149 million YLDs, accounting for 17% of all YLDs worldwide.

Low back pain is the main contributor to the overall burden of musculoskeletal conditions (570 million prevalent cases worldwide, responsible for 7.4% of global YLDs). Other contributors to the overall burden of musculoskeletal conditions include fractures with 440 million people globally (26 million YLDs), osteoarthritis (528 million people; 19 million YLDs), neck pain (222 million people; 22 million YLDs), amputations (180 million people; 5.5 million YLDs), rheumatoid arthritis (18 million people; 2.4 million YLDs), gout (54 million people; 1.7 million YLDs) other musculoskeletal conditions (453 million people; 38 million YLDs) [data from IHME Viz Hub and WHO Rehabilitation Needs Estimator].

While the prevalence of musculoskeletal conditions increases with age, younger people are also affected, often during their peak income-earning years. For example, childhood auto-immune inflammatory conditions such as juvenile arthritis affect children’s development, while low back pain is the main reason for a premature exit from the workforce. The societal impact of early retirement in terms of direct health-care costs and indirect costs (i.e., work absenteeism or productivity loss) is enormous. Projections show that the number of people with low back pain will increase in the future, and even more rapidly in low-income and middle-income countries (3).

https://www.who.int/news-room/fact-sheets/det...conditions

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