If we don't have efficacy by Aug would that shock

If we don't have efficacy by Aug would that shock you, mildly surprise you, or not surprise you?

I realize we have to stay conservative in our thinking til the final goal is reached (efficacy/low toxicity) but right now I have to think most all here are feeling like the chances for success keep shifting toward our side and by Aug it should be fully in place.

The only difference between us is you know what you are talking about.  LOL.