There are undoubtedly individuals and very small g

There are undoubtedly individuals and very small groups within the FDA who are willing to subvert the process of approval. However there is no proof of an overarching conspiracy to crush the small biopharmas. So to say it is a MUST is a little bit overboard. The Freemasons do not control the world.

In support of my contention I looked at approvals of novel drugs in 2021. there were 50 drugs approved. Of those 50 drugs, 15 seemed to come from small biopharmas that did not have a development deal in place prior to approval. My look for partnerships was not exhaustive so I may be wrong on a few.

Argenx - Vyvgart
Mirum Pharmaceuticals - Livmarli
Ascendis Pharma - Skytrofa
Albireo Pharma - Bylvay
Kadmon Corporation - Rezurock
SCYNEXIS - Brexafemme
QED Therapeutics/BridgeBio Pharma - Truseltiq
Lantheus Holdings - Pylarify
ADC Therapeutics - Zynlonta
Mayne Pharma Group/Mithra Pharmaceuticals - Nextstellis
Supernus Pharmaceuticals - Qelbree
AVEO Oncology/EUSA Pharma - Fotivda
Origin Biosciences/BridgeBio Pharma - Nulibry
G1 Therapeutics - Cosela
Aurinia Pharmaceuticals -Lupkynis