Leronlimab is effective here in lower doses becaus
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Posted On: 07/17/2022 1:10:58 PM
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Leronlimab is effective here in lower doses because, unlike in cancer and tumor, there is not an excessive overexpression of CCR5 so only 350mg is necessary.
https://www.reddit.com/r/LeronLimab_Times/com...;context=3
With the large amount of inflammatory cytokines involved in NASH, one would expect an overexpression of CCR5 and there is. One should not let pre-conceived notions interfere with facts.
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CCL5 is a natural ligand for the chemokine receptor CCR5. CCR5 also plays a central role in all the events related to the remodelling of liver matrix, and it has been observed that patients with chronic liver disease show high levels of CCR5 and CCL5.
https://academic.oup.com/jac/article/69/7/1903/2911132
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The CC chemokines MIP-1α, MIP-1β, and RANTES and their receptors CCR1 and CCR5 were strongly upregulated in 2 experimental mouse models of fibrogenesis.
https://www.jci.org/articles/view/37444
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