This is why I believe Jemperli and Leronli would m
Post# of 148288
In the PD 1 trial, they found that there were excessive PD1 receptors on the surfaces of the T cells. In the LRM trial, there were too few CCR5 receptors.
In the PD 1 trial, giving PD1 blockade restored normal t cell function and eradicated exhaustion.
In the LRM trial, giving LRM restored normal t cell function and eradicated exhaustion.
People continue to suffer with LH. Some people still can't smell or taste. Some have fatigue, headaches. The t cells remain exhausted until they get fixed, but with out the appropriate treatment, they don't get better on their own. PD 1 blockade or CCR5 blockade apparently is necessary as per the trials.
NIH was considering grant for LH.