Goose, I think this is excellent thinking as well.
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Posted On: 07/12/2022 8:41:33 PM
Re: Goosebumps #126330
Goose, I think this is excellent thinking as well.
I sure as hell hope Jonas will be successful, but from an earlier conversation I had, it seems like it will be difficult, but I hope he will figure out a way to get it done.
The reason is that the gene capsid that gets translated into the monoclonal antibody protein LRM is itself not replicated when the original T cell divides to multiply during mitosis.
In the initial LRM AAV transfusion, lets say 5 billion T cells and B cells in the patient's body are "infected" by this adeno virus vector, and infects these cells with the gene capsid which when translated, makes LRM. Well, when these 5 billion Immune cells go to divide and multiply, they will not copy & multiply that gene, but that gene will only remain in the initial T or B cell, but will not end up in the daughter cell.
Therefore, the capacity of the body to maintain the full manufacture of LRM will slowly fade out as the original T and B cells die off in their respective time frames. T cells have different roles. T helper, T regulator, T memory, Th1, Th2, CD toxic, CD4, CD8, Cytotoxic lymphocytes, etc. All of these have different half lives. Some may die off as early as a few months, some may die off in a year, some 3 or 4 years, some 6 or 8 years.
The other thing is that currently, they don't do more than one AAV transfusion in a patient's lifetime, because after the 1st one your body develops antibodies to the adenovirus and on the 2nd transfusion, your body could mount an attack against the infusion which could injure or harm the patient.
Anyway, they got the grant and Jonas should get this to work. And if he does, exactly what you're predicting could become a reality. But, it would only benefit you if you had HIV.
Unless of course, we got the AAV transfusion indicated for any of the ohm list of ailments and then you could get it for any and then be cured of all.
But you have to wonder then, why is CCR5 there? chemokine, chemotaxis, but it seems like CCR5 benefits metastasis and tumors more than anything beneficial in the immune system, and patients have done very well for over 8 years with all their CCR5 completely blocked by LRM 100% RO, so, bring on the CCR5 blockade, is what I would say.
I sure as hell hope Jonas will be successful, but from an earlier conversation I had, it seems like it will be difficult, but I hope he will figure out a way to get it done.
The reason is that the gene capsid that gets translated into the monoclonal antibody protein LRM is itself not replicated when the original T cell divides to multiply during mitosis.
In the initial LRM AAV transfusion, lets say 5 billion T cells and B cells in the patient's body are "infected" by this adeno virus vector, and infects these cells with the gene capsid which when translated, makes LRM. Well, when these 5 billion Immune cells go to divide and multiply, they will not copy & multiply that gene, but that gene will only remain in the initial T or B cell, but will not end up in the daughter cell.
Therefore, the capacity of the body to maintain the full manufacture of LRM will slowly fade out as the original T and B cells die off in their respective time frames. T cells have different roles. T helper, T regulator, T memory, Th1, Th2, CD toxic, CD4, CD8, Cytotoxic lymphocytes, etc. All of these have different half lives. Some may die off as early as a few months, some may die off in a year, some 3 or 4 years, some 6 or 8 years.
The other thing is that currently, they don't do more than one AAV transfusion in a patient's lifetime, because after the 1st one your body develops antibodies to the adenovirus and on the 2nd transfusion, your body could mount an attack against the infusion which could injure or harm the patient.
Anyway, they got the grant and Jonas should get this to work. And if he does, exactly what you're predicting could become a reality. But, it would only benefit you if you had HIV.
Unless of course, we got the AAV transfusion indicated for any of the ohm list of ailments and then you could get it for any and then be cured of all.
But you have to wonder then, why is CCR5 there? chemokine, chemotaxis, but it seems like CCR5 benefits metastasis and tumors more than anything beneficial in the immune system, and patients have done very well for over 8 years with all their CCR5 completely blocked by LRM 100% RO, so, bring on the CCR5 blockade, is what I would say.
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