Sangamon and others gave tried CCR5 KO without muc

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Sangamon and others gave tried CCR5 KO without much success

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Took a look at Sangamo. What they were trying to do was break the DNA at the CCR5 gene region and hope there were errors in the DNA repair. The results showed that only a portion of the CD4/8 cells were actually modified. The problem could be as simple as DNA repair being better than expected.