Quote:So 700 normal doesn't reduce TNF-a?.
No, not when it is being used to treat NAFLD, it doesn't reduce TNF alpha. Looking at the heat map, that rectangle is either black or has a twinge of red in it.
Again, we don't know their starting cT1 ms like we did know the 350mg, but to be included in the study, they had to have starting cT1 > 800ms.
In the study you referenced, I think that was 700mg, but not sure. Regardless, it was in Covid, not NASH.
Here, we are dealing with NASH and more likely NAFLD. (I feel like the liver and an even lesser degree of the overall problem being NAFLD vs NASH is a significantly smaller problem to have than is Cytokine Storm, so NAFLD and NASH seem to do better with a lesser dose of LRM like 350mg except in the case of the HM group where 700mg performed well, but 350mg wasn't tested in this group either.) 700 seems to push a topsy system like NAFLD or mild NASH into the inflammatory mode and moves it away from the metabolism of fibrosis mode, (anti-inflammatory mode). 700mg is more appropriate in severe disease like Cytokine Storm or Covid Severe-Critical.
Slamming these NASH/NAFLD patients with 700mg divided the overall outcome with a weighting toward an increase in the macrophage attack of the dying hepatocyte mode, (which is what you want to overcome Cytokine Storm), over the metabolism of fibrosis mode.
In this patient group of NAFLD - NASH, 700mg was given, and there was minimal fibrosis to begin with, so system exited the metabolism of fibrosis mode and entered the macrophage attack mode of the dying hepatocytes where inflammation was either maintained or slightly increased with the output of Nitric Oxide from the CD 8 T cells as Bruce mentions, along with reactive oxygen species where the dying hepatocytes were summoning the help of the immune system via cytokine recruitment, thereby maintaining TNF alpha levels unchanged.
