Thanks Emmitt, My initial thought on this is th
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Posted On: 06/20/2022 9:24:46 PM
Thanks Emmitt,
My initial thought on this is that may be a difficult pill to swallow. Sepsis does not give a patient much time. Usually, the body will depend upon the Innate Immune Response to overcome the bacterial load. To get the Adaptive Immune System onboard requires many days, look how long it takes to become immune to a variant of Covid 19, it could be 2 weeks before you feel somewhat recovered.
Leronlimab primarily works on the Adaptive Immune Response and not as much in the Innate. CCR5 receptors are found on cells of the Adaptive Immune System in far more quantity than on cells of the Innate Immune System. There will some overlap, but the balance is in the favor of the Adaptive.
To overcome sepsis, the response needs to be powerful and swift. Antibiotics is the weapon of choice right now and in combination with LL, could be a good strategy.
Why? Because, if there is a multi-drug resistant organism, which is mildly sensitive to an antibiotic, possibly the antibiotic could hold the organism at bay while providing the time necessary to ramp up the Adaptive Response to develop the specific T cells with receptors designed to identify the specific bacteria which it needs to destroy.
I think this would be a way it could work, but in combination with another antibiotic which would hold the organism at bay while the Adaptive Immune System designs it's specific weaponry for the antigen.
My initial thought on this is that may be a difficult pill to swallow. Sepsis does not give a patient much time. Usually, the body will depend upon the Innate Immune Response to overcome the bacterial load. To get the Adaptive Immune System onboard requires many days, look how long it takes to become immune to a variant of Covid 19, it could be 2 weeks before you feel somewhat recovered.
Leronlimab primarily works on the Adaptive Immune Response and not as much in the Innate. CCR5 receptors are found on cells of the Adaptive Immune System in far more quantity than on cells of the Innate Immune System. There will some overlap, but the balance is in the favor of the Adaptive.
To overcome sepsis, the response needs to be powerful and swift. Antibiotics is the weapon of choice right now and in combination with LL, could be a good strategy.
Why? Because, if there is a multi-drug resistant organism, which is mildly sensitive to an antibiotic, possibly the antibiotic could hold the organism at bay while providing the time necessary to ramp up the Adaptive Response to develop the specific T cells with receptors designed to identify the specific bacteria which it needs to destroy.
I think this would be a way it could work, but in combination with another antibiotic which would hold the organism at bay while the Adaptive Immune System designs it's specific weaponry for the antigen.
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