Another way that CCR5 induces NASH. CCL5 binding to CCR5 promotes the migration of adenosine deaminase 2 (ADA2) to the liver. ADA2 then upregulates platelet derived growth factor-B (PDGF-
which is a primary pro-fibrotic cytokine. Leronlimab of course stops the migration of ADA2 bearing monocytes.
It took me a bit of time to trace that one out.