From my experience with radiotherapy fibrosis and

From my experience with radiotherapy fibrosis and hyperbaric oxygen therapy, it was felt as time went on with the fibrotic injury, an ischemic bulls-eye type of effect occurred. There was a progressive ischemia from the normal tissue toward the central area of the fibrosis without enough of an oxygen gradient along the way to induce angiogenesis into the fibrotic tissue to help reverse it. The hyperbaric oxygen therapy led to a big oxygen gradient and stimulated angiogenesis into the fibrotic tissue by increasing the oxygen gradient at the periphery and working its way to the severely ischemic central scarring.. With enough treatments you could greatly diminish if not completely reverse the radiation fibrotic injury. Maybe angiogenesis brought on somehow by CCR5 blockade is part of it. Just a thought.